George Kargul, M.D., MS

Assistant Professor, Medicine

Biography

George Kargul, M.D., MS, earned an undergraduate degree in mathematics at the University of Michigan. After earning a master of science in general biology at Wayne State University, he was awarded a pre-IRTA fellowship to work at the Laboratory of Genetics at the NIA/NIH. While at the NIH, his work included informatics research in genomic sequence analysis, mouse developmental genomics and the development of the largest mammalian cDNA microarray at that time.

Following his fellowship at NIA/NIH, Dr. Kargul earned a medical degree from Wayne State University and completed a residency in internal medicine at Thomas Jefferson University Hospitals. During his residency, he also served as a research proposal reviewer for The Implementation Group, a Washington, DC-based consulting firm which helps researchers and organizations acquire federal funding.

Dr. Kargul joined the CIMS faculty following his residency. His current academic interests include genomics, informatics and hospital medicine. He is a member of the American Medical Association, the Pennsylvania Medical Society, the American Psychiatric Association, the Wayne State University Alumni Association and the Society of Physics Students. He also was awarded a lifelong membership in the mathematics honor society, Pi Mu Epsilon.

Publications

• Carter MG, Piao Y., Dudekula D.B., Qian Y., VanBuren V., Sharov A.A., Tanaka T.S., Martin P.R., Bassey U.C., Stagg C.A., Aiba K., Hamatani T., Matoba R., Kargul G.J., Ko M.S. The NIA cDNA project in mouse stem cells and early embryos. CR Biology 328: 931-940, October 2003.
   
• VanBuren V., Piao Y., Dudekula D.B., Qian Y., Carter M.G., Martin P.R., Stagg C.A., Bassey U.C., Aiba K., Hamatani T., Kargul G.J., Luo A.G., Kelso J., Hide W, Ko M.S. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. Genome Research 12: 1999-2003, December 2002.
   
• Kargul, G.J., Dudekula, D.B., Qian, Y., Lim, M.K., Jaradat, S.A., Tanaka, T.S., Carter, M.G., and Ko, M.S.H. Verification and initial annotation of the NIA mouse 15K cDNA clone set. Nature Genetics 28: 17-18, May 2001.
   
• Barrett, T., Xie, T., Piao, Y., Dillon-Carter, O., Kargul, G.J., et al. A murine dopamine neuron-specific cDNA library and microarray: increased COX1 expression during methamphetamine neurotoxicity. Neurobiology of Disease 8: 822-833 October 2001.
   
• Kargul, G.J., Nagaraja, R., Shimada, T., Grahovac, M.J., Lim, M.K., Nakashima, H., Waeltz, P., Ma, P., Chen, E., Schlessinger, D., Ko, M.S. Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Research 10: 916-923, July 2000.
   
• Ko, M.S., Kitchen, J., Wang, X., Threat, T., Wang, X., Hasagawa, A., Sun, T., Grahovac, M., Kargul, G.J., et al. Large-scale cDNA analysis reveals phased gene expression patterns during pre-implantation mouse development. Development 127:1737-1749. April 2000.
   
• Tanaka, T.S., Jaradat, S.A., Lim, M.K., Kargul, G.J., et al. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. PNAS 97: 9127-9132. August 2000.