Bahman Saatian, M.D.

Instructor, Medicine

Biography

Bahman Saatian, M.D., earned a medical degree at Azad University of Tehran, Iran. His desire to learn about the basic mechanisms of diseases led him to join a post- doctoral research fellowship at The Johns Hopkins University Bloomberg School of Public Health, followed by the School of Medicine.

Dr. Saatian also completed a residency in internal medicine at Good Samaritan Hospital of Maryland.

Publications

• S. N. Georas, E. Berdyshev, W. Hubbard, I. A. Gorshkova, P. V. Usatyuk, B. Saatian, A. C. Myers, M. A. Williams, H. Q. Xiao, M. Liu, V. Natarajan. Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge. Clin Exp Allergy. 2007 Mar; 37(3):311-22.
   
• Waters CM. Saatian B. Moughal NA. ZhaoY. Tigyi G. Natarajan V. Pyne S. and Pyne NJ. Integrin signalling regulates the nuclear localisation and function of the lysophosphatidic acid receptor-1 (LPA 1) in mammalian cells. Biochem J. 2006 Aug 15; 398 (1):55-62.
   
• Zhao Y., He D., Saatian B., Watkins T., Spannhake E.W, Pyne NJ., and Natarajan V. Regulation of lysophosphatidic acid- induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase C delta , Lyn kinase and matrix metalloproteinases. J Biol Chem. 2006 Jul 14;281 (28):19501-11.
   
• Berdyshev, E.V., Gorshkova, I. A., Usatyuk, P., Zhao, Y., Saatian, B., Hubbard, W. and Natarajan, V. De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. Cell Signal. 2006 Oct; 18 (10):1779-92.
   
• Saatian, B., Zhao, Y., He, D., Georas, S.N., Watkins, T., Spannhake, E.Wm., and Natarajan, V. Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. Biochem J. 2006 Feb. 1; 393(pt 3):657-68.
   
• Chowdhury, A.K., Watkins, T., Kleinberg, M. A., Saatian, B , Usatyuk, P.V. and Natarajan, V. Src-mediated Tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells. J Biol Chem. 2005 May 27; 280(21):20700-11.
   
• Zhao, Y., Usatyuk, P.V., Cummings, R., Saatian, B, He, D., Watkins, T., Morris, A., Spannhake, E.W., Brindley D.N., and Natarajan V. Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-B activation and IL-8 secretion in human bronchial epithelial cells. Biochemistry J. 2005 Jan 15, 385(Pt 2):493-502.
   
• Cummings, R., Zhao, Y., Jacoby, D.B., Spannhake, E.W., Ohba, M., Garcia, J.G.N, Watkins, T., He, D., Saatian, B, and Natarajan, V. Protein Kinase C Mediates Lysophosphatidic Acid-Induced NFB Activation and Interleukin-8 Secretion in Human Bronchial Epithelial Cells. J Biol Chem. 2004 Sep 24; 279(39): 41085-41094.
   
• Saatian, B, Yu, X-Y., Lane, A. P., Doyle, T., Casolaro, V., and Spannhake, E.W. Expression of Genes for B7-H3 and other T Cell Ligands by Nasal Epithelial Cells During Differentiation and Activation. Am J Physiol Lung Cell Mol Physiol, 2004 Jul., 287(1): L217-25.
   
• Lane, A.P., Saatian, B, Yu, X-Y., and Spannhake, E.W. mRNA for genes associated with antigen presentation are expressed by human middle meatal epithelial cells in culture. Laryngoscope, 2004 Oct; 114(10):1827-32.
   
• Spannhake, E.W., Reddy, S.P.M., Jacoby, D.B., Yu X-Y., Saatian, B, Tian, J. Synergism between Rhinovirus Infection and Oxidant Pollutant Exposure Enhances Airway Epithelial Cell Cytokine Production. Environ. Health Perspec. July 2002.110(7): 665-70.