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Inflammatory Bowel Disease (IBD)

It’s estimated that as many as a million Americans suffer from inflammatory bowel disease or IBD. It can affect anyone, but occurs most frequently in people ages 15 to 30. The most cases of IBD are reported in North America and Western Europe.


 
Johns Hopkins Bayview News,
 February 2008

What Is IBD?

Inflammatory bowel disease (which is not the same thing as irritable bowel syndrome, or IBS) refers to two chronic diseases that cause inflammation of the intestines: ulcerative colitis and Crohn's disease. Although the diseases have some features in common, there are some important differences.

Ulcerative colitis is an inflammatory disease of the large intestine, also called the colon, and can develop ulcers. It’s often the most severe in the rectal area, which can cause frequent diarrhea. Mucus and blood often appear in the stool if the lining of the colon is damaged.

Crohn's disease differs from ulcerative colitis in the areas of the bowel it involves - it most commonly affects the last part of the small intestine and/or parts of the large intestine. However, Crohn's disease isn't limited to these areas and can attack any part of the digestive tract. Crohn's disease causes inflammation that extends much deeper into the layers of the intestinal wall than ulcerative colitis does. Crohn's disease generally tends to involve the entire bowel wall, whereas ulcerative colitis affects only the lining of the bowel.
 

What Causes IBD?

Medical research hasn't determined yet what causes inflammatory bowel disease. But researchers believe that a number of factors may be involved, such as the environment, diet and genetics.

Current evidence suggests that there are genetic defects that affects how our immune system works and how the inflammation is turned on and off in those people with inflammatory bowel disease, in response to an offending agent, like bacteria, a virus or a protein in food.

The problem in people with the disease is that the inflammation gets turned on, but it doesn't get turned off. In Crohn’s Disease, the normal intestinal bacteria are a target for the inflammation. Medical evidence also indicates that smoking may enhance the likelihood of developing Crohn's disease.
 

What Are the Symptoms of IBD?

The most common symptoms of IBD are diarrhea and abdominal pain. Other common signs can include:

  • Nausea
  • Loss of appetite
  • Weight loss
  • Frequent fever
  • Rectal bleeding
  • Low levels of iron in the blood (anemia)
  • Exhaustion
  • Sometimes, constipation
     

When Should I Call My Doctor?

It is important to call your doctor if you see blood in the stool, have a change in bowel habits that last more than 10 days, or if you have any of the following symptoms that do not improve with over-the-counter medicines:

  • Severe abdominal cramps or pain
  • Severe diarrhea or bloody diarrhea
  • Weight loss
  • Unexplained fever lasting more than 3 or 4 days
  • Exhaustion
  • Loss of appetite
  • Nausea
     

How Is Inflammatory Bowel Disease (IBD) Treated?

Here at the Center for Digestive Diseases we treat IBD in order to improve symptoms and decrease the amount of inflammation. Your treatment plan could include:

  • Dietary changes
  • Lifestyle changes like stress reduction
  • Medicine
  • Surgery
     

The personalized treatment plan we make with you depends on the type and severity of symptoms, location of disease and possible complications.

People who have mild or no symptoms may not need treatment at all; however, most people with IBD take medicine to control their symptoms. Many with severe IBD need surgery to control the disease.
 

What Types of Surgery Are Used to Treat Inflammatory Bowel Disease (IBD)?

There are different types of surgery used to treat IBD.

Surgery for Crohn's Disease

Over half of people with CD need surgery at some point in their life. Surgery can relieve symptoms and correct problems like blockages, fistulae or bleeding in the intestine. After surgery, some people are able to stop taking daily medicines for CD.

Surgery can help relieve the symptoms of CD but cannot cure it. The inflammation tends to return next to the part of intestine that was removed. So, people considering surgery for CD should carefully weigh the risks and benefits.

Types of surgery for CD include:

  • Stricturoplasty
    In this surgery, the doctor opens up an area of the intestine that has gotten smaller because of CD. The area of the intestine that has narrowed is called a stricture. The doctor does not remove any of the intestine in this surgery.
      
  • Small bowel resection
    In this surgery, the damaged part of the intestine is removed and the two healthy ends are sewn back together.
     
  • Colectomy
    In this surgery, the doctor removes a part of the colon or the entire colon and rectum. The body needs the colon to move and get rid of waste. So after a colectomy the doctor must create a new way for waste to leave the body. This is now usually done by making an opening in the abdomen called a stoma. This hole allows for the drainage of stool from the large or small intestine. A pouch is worn over the opening to collect waste.
     

Surgery for Ulcerative Colitis

About 20 to 40 percent of people with UC need surgery at some point in their lives. The types of surgery for UC include:

  • Proctocolectomy
    The doctor removes the entire large intestine including the colon, rectum and anus during this surgery. This is the most commonly recommended surgery for people with UC. It can be performed with an iIeostomy or ileoanal pouch anal anastomosis (IPAA). For more details on these procedures see the section above on surgery for CD.
     
  • Ileal pouch anal anastomosis (IPAA)
    In this procedure, the very end of the small intestine (ileum) is made into a pouch. It is then connected to the anus. In this way, waste can once again leave the body through the anus. People who have IPAA do not need to wear a pouch outside their bodies. But people who have IPAA have more complications than those who have an ileostomy. The most common problems with this surgery are blockages in the intestine and pouch inflammation or infection.
     

To schedule an appointment with a Johns Hopkins gasteroenterologyist or hepatologist at any of our locations, call 410-550-0790 or fax a referral to 410-550-7861.





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