Research & Clinical Trials - Johns Hopkins Bayview Medical Center

ADD/ADHD

1. Do You Have ADD/ADHD?
Men and women ages who have been diagnosed with ADD or ADHD are needed for a two-day outpatient study at the Johns Hopkins University School of Medicine in Baltimore, Maryland. Volunteers with ADHD who have used medications for the treatment of ADHD and those who have never used medications for the treatment of ADHD are needed.

Volunteers should be between the ages of 18 and 40 and in general good health. Testing will take place at the Johns Hopkins Hospital and Johns Hopkins Bayview Medical Center. Study participants will receive compensation, and travel expenses will be covered. Earn up to $300 plus travel expenses.

For more information, call 410-550-6266 or 410-550-2588.

Collect calls are accepted.

Principal Investigator: Una D. McCann, MD
IRB Number: NA_00033609

2. Children Ages 8-12 Needed to Participate in Brain Research on ADHD

Stewart Mostofsky, M.D., and his colleagues in the Laboratory of Neurocognitive and Imaging Research at Kennedy Krieger Institute are recruiting children 8-12 years of age to participate in a research study of attention, response planning and inhibitory control. This study will examine the brain basis of ADHD in children. Children with ADHD are needed, as well as those who do not have ADHD to participate as “comparison subjects”. The study involves paper and pencil tasks, computer activities and a Magnetic Resonance Imaging (MRI) of the brain. None of these tests are harmful or painful. There are no direct medical benefits from taking part in the study. The study involves two days of testing and MRI.

Participants will receive $100 and a picture of their brain. Parents will receive a report of the IQ test administered to their child. All testing is done free of charge.

For more information or to enroll, please contact Kristie Sweeney at (443) 923-9254.

PI: Stewart Mostofsky, M.D.

Aging

1. Are You 70 Years of Age or Older?
Investigators from the Division of Geriatric Medicine at Johns Hopkins Bayview are looking for individuals, aged 70 years or older, to participate in a research study looking at the aging process.

Tests would include measurements of strength, walking speed and questions about your physical activities. We also request a blood draw.

You willl be paid $10 for participating. The study can be done in your home. Or, if you choose to travel to the Medical Center, your parking costs will be covered.

For more information, please call 410-550-2113.

PI: Jeremy Walston, M.D.
NA_00052046

2. Are you between the ages of 20 and 30? Are you interested in medical research?
Investigators from the Division of Geriatric Medicine at Johns Hopkins are looking for healthy individuals, ages 20 to 30, to participate in a research study that will identify the differences in hormone and immune system cells between younger and older individuals.

Participation involves answering a questionaire about your medical history and a blood draw.

You will be paid $10 for participating. Your parking costs will be covered.

For more information, please call 410-550-2113.

PI: Jeremy Walston, M.D.

3. Are You 70 Years or Older?
Investigators from the Division of Geriatric Medicine at Johns Hopkins are looking for individuals, aged 70 years or older, to participate in a research study looking at the effects of nutritional supplements on aging.

Screening questions will be asked regarding your health and physical activity. If you're eligible, we will ask you to donate a blood sample. Based on these results, we may ask you to participate in a more detailed study of nutritional supplementation. Home visits are available if you cannot come to Johns Hopkins Bayview. Upon completion of the study, you will be paid $50.

For more information, please call 410-550-2113.

PI: Jeremy Walston, M.D.
NA_00002109

4. Are You Over 60 and Feeling Depressed?
Are you over 60 and feeling depressed? Symptoms of depression in older adults are common yet often go undetected. They could include feelings of sadness or hopelessness, loss of energy, inability to enjoy pleasurable activities, changes in appetite or sleeping patterns, or poor concentration/memory.

If you are feeling depressed, not taking antidepressant medication and in good physical health you may be eligible to participate in a research study involving treatment. Qualified people will participate at no cost to them and will be compensated for their time and transportation.

For more information about the research study, please call 410-550-4192.

Principal Investigator: Gwenn Smith, Ph.D.
NA_000021615

5. Are You Over 60 and Interested In Research?
We are conducting brain imaging research using a technique called Positron Emission Tomography, or PET for short, to take pictures of the brain. If you are in good health and aren’t taking medications that affect the brain, you may qualify for participation. Qualified people will participate at no cost to them. Compensation for time and transportation will be provided.

For more information, please call 410-550-4192.

Principal Investigator: Gwenn Smith, Ph.D.
NA_000021615

6. Are you between the ages of 18 and 50 years?
Investigators from the Division of Geriatric Medicine at The Johns Hopkins University are looking for healthy individuals between the ages of 18 and 50 to participate in a research study that will identify the differences in hormone and immune system cells between older and younger individuals.

Participation involves answering a questionnaire about your medical history, as well as a blood draw and urine collection.

Participants will be paid $20. Parking costs also will be covered.

For more information, please call 410-550-2113.

PI: Jeremy Walston, M.D.
NA_00052046

Anxiety/Depression

1. Are You Over 60 and Feeling Depressed
Are you over 60 and feeling depressed? Symptoms of depression in older adults are common yet often go undetected. They could include feelings of sadness or hopelessness, loss of energy, inability to enjoy pleasurable activities, changes in appetite or sleeping patterns, or poor concentration/memory.

For more information about the research study, please call 410-550-4192.

Principal Investigator: Gwenn Smith, Ph.D.
NA_000021615

2. Child Gaining Weight on Medication?
Mark Riddle, M.D., and colleagues in the Johns Hopkins Division of Child and Adolescent Psychiatry are conducting a treatment research study funded by the National Institute of Mental Health. The goal of the study is to find improved treatments for youth who have a have gained weight while taking antipsychotic medication.

We are currently seeking children ages 8-19 who are taking olanzapine (Zyprexa®), quetiapine (Seroquel®), risperidone (Risperdal®), aripiprazole (Abilify®), or ziprasidone (Geodone®) and have gained a significant amount of weight in the past year while taking one of these medications. Consenting children who meet eligibility criteria will receive a medical and psychiatric evaluation and will be assigned to one of three groups: 1) stay on current medication, 2) switch from current medication to aripiprazole (Abilify®) or perphenazine (Trilafon®), 3) stay on current medication and add metformin (Glucophage®). Participants receive study-related evaluations and treatment at no cost.

For further information, call 410-614-5174.

PI: Mark Riddle, M.D.
IRB #00017204

Arthritis

1. Do You Have Knee Arthritis?
Volunteers are needed for a sleep and sensory testing study. Researchers at The Johns Hopkins University School of Medicine are looking for volunteers to participate in a research study examining the association between sleep and sensory abilities in arthritis.

To participate in this study, you must:

Be 50 years of age or older;
Have osteoarthritis of the knee;
Have knee pain; and
Either have trouble sleeping or be a good sleeper.

This study involves:

Two sleep studies conducted in your home; and
Sensory testing at Johns Hopkins.

All examinations, parking and tests are provided at no cost. Participants will be compenstated up to $110.

For more information on the study or to see if you are eligible, please call 410-550-7906 or visit our Web site: www.sleeplessinbaltimore.com.

PI: Michael T. Smith, Ph.D.
Protocol: NA_00011802

Asthma/Allergy

1. Do you have allergies to cats, eggs, milk or peanuts?
Researchers at Johns Hopkins are looking for volunteers who are allergic to cats, milk, eggs or peanuts for ongoing and future studies at the Johns Hopkins Asthma & Allergy Center. You will be paid for study participation.

For more information or to apply, call 410-550-2200. For more ongoing allergy studies, visit www.hopkinsmedicine.org/allergy.

Principal Investigator: Bruce Bochner, M.D.
IRB# NA_00006137

2. Researchers at Johns Hopkins Are Looking for Healthy Volunteers
No allergies? No asthma? Researchers at Johns Hopkins are looking for healthy volunteers for ongoing and future studies at the Johns Hopkins Asthma & Allergy Center. You will be paid for study participation.

For more information or to apply, call 410-550-2200. For more ongoing allergy studies, visit www.hopkinsmedicine.org/allergy.

Principal Investigator: Bruce Bochner, M.D.
IRB# NA_00006137

3. Do you have asthma?
Do you have asthma? Researchers at Johns Hopkins are looking for volunteers with asthma for ongoing and future studies at the Johns Hopkins Asthma & Allergy Center. You will be paid for study participation.

For more information or to apply, call 410-550-2200. For more ongoing allergy studies, visit www.hopkinsmedicine.org/allergy.

Principal Investigator: Bruce Bochner, M.D.
IRB# NA_00006137

4. Are you allergic to peanuts?
Researchers at Johns Hopkins are seeking adults (18+) with peanut allergy for a research study to treat peanut allergy. We will use an injectable drug that is FDA-approved for asthma. You will be compensated for participating in this 12-month study.

For more information, please call 410-926-4918.

PI: Robert Wood, M.D.
NA_00026397

5. DO YOU SUFFER WITH FALL ALLERGIES? DO YOU HAVE RAGWEED ALLERGY IN AUGUST & SEPTEMBER?
The Johns Hopkins Asthma & Allergy Center is looking for volunteers to join an 18-month research study with 11 office visits. The study will test an experimental oral medicine for ragweed allergies.

Participants must be between 18 and 50 years of age, have fall ragweed allergies and not be on allergy shots. Participants will be paid for their time.

For more information or to enroll in the study, call 410-550-2122.

Principal Investigator: Peter S. Creticos, M.D.
NA_00031323

6. DO YOU HAVE NASAL POLYPS?
The Johns Hopkins Asthma & Allergy Center is looking for volunteers to join an 18-week research study with six visits. The study will test an experimental nasal spray for nasal polyps.

Participants must be between 18 and 70 years of age, have nasal polyps and not be pregnant or breastfeeding. Participants will be paid for their time.

For more information or to enroll in the study, call 410-550-2122.

Principal Investigator: Peter S. Creticos, M.D.
NA_00029405

7. Ongoing Asthma Study
Have you participated in past studies related to lung health, asthma or home environmental air quality at the Johns Hopkins Asthma & Allergy Center? If so, we would like to hear from you.

If you are African American, with or without asthma, we invite you to call 410-550-2188 to learn more about an ongoing asthma study. Children under 18 must have parental consent. You will be compensated for your time.

PI: Kathleen C. Barnes, Ph.D.
NA_00035214

Autism

1. Participate in Brain Research on High Functioning Autism

Stewart Mostofsky, M.D., of the Kennedy Krieger Institute and The Johns Hopkins University School of Medicine is recruiting children with and without high-functioning autism, between 8-12 years of age to participate in a study of attention, learning, memory and motor skills. The study involves paper and pencil tasks, computer activities and an MRI scan of the brain. None of the tests are harmful or painful and are done free of charge.

There are no direct medical benefits for participating in the study. The duration of the study is two to three days. Participants will receive a $100 check and a picture of their brain. Parents will receive a report summarizing the IQ testing administered to their child.

For more information or to enroll, please contact Katarina Ament at (443) 923-9273.

PI: Stewart Mostofsky, M.D.

Brain Imaging/Mapping

1. Volunteers Needed for Research on Brain Imaging of Cognitive Function
We are looking for people to participate in studies involving either fMRI (functional magnetic resonance imaging) or TMS (transcranial magnetic stimulation) or both.?Studies take between 1 hour to 4 hours total, and you will be compensated $20/hour for your time.

To be eligible to participate, you must:

be 60-70 years old;
be a native speaker of English (ie, have learned English before the age of 5);
be right handed;
have a social security number or taxpayer ID (so we can pay you!);
have no history of neurological disorders;
have no unremovable metal in your body (fillings in teeth are ok);
have no history of claustrophobia; or,
have no history of heart or respiratory disease, seizures or strokes (for TMS studies).

For more information on fMRI and/or TMS, log on to www.jhu.edu/nimlab. To participate in this study, call 410-502-5151.

Johns Hopkins Protocol Number: 05-06-01-03
Principal Investigator: John E. Desmond, Ph.D.

2. Do you smoke cigarettes?
If so, you may be able to participate in research studies to see how smoking affects the body and brain. The studies take place in East Baltimore and are sponsored by the National Institute on Drug Abuse (NIDA), National Institutes of Health, U.S. Department of Health and Human Services.

You will be paid for your time and travel.

For a confidential screening, call 800-535-8254 or 443-740-2295 or visit www.ResearchStudies.DrugAbuse.gov.

10.10.2012

Cancer

1. Seeking Volunteers with a Cancer Diagnosis to Participate in a Scientific Study of Self-Exploration and Personal Meaning
In recent years, scientists at some US universities have been conducting studies using entheogens, resuming research in pharmacology, psychology, creativity and spirituality that was suspended following the drug excesses of the 1960s.

Entheogens include the peyote cactus used by the Native American Church, the psilocybin-containing mushrooms used as sacraments in Mesoamerica, and certain other plants and chemicals. Such substances have been used for thousands of years in cultures from the Amazon to ancient Greece as a means of inducing non-ordinary states of consciousness for psychological self-exploration and spiritual or religious purposes.

These states of consciousness are most widely known in connection with practices such as meditation and prolonged fasting. Context seems to play a major role in shaping entheogen experiences and their consequences. Despite the well-known problems that can arise in unstructured settings, the risks of entheogens in research and ritual contexts have proven to be very small.

Researchers at The Johns Hopkins University School of Medicine are seeking volunteers with a current or past diagnosis of cancer who have some anxiety or are feeling down about their cancer to participate in a scientific study of self-exploration and personal meaning brought about by the entheogen psilocybin, a psychoactive substance found in mushrooms used as a sacrament in some cultures, given in a comfortable, supportive setting. Questionaires and interviews will be used to assess the effects of the substance on consciousness, mood and behavior.

Volunteers enrolled in the study will receive careful preparations and two sessions in which they will receive psilocybin. Structured guidance will be provided during the session and afterwards to facilitate integration of the experiences. The study complies with FDA regulations.

Volunteers must be between 21 and 70 years of age, have no personal history of severe psychiatric illness, or recent history of alcoholism or drug abuse, and have someone willing to pick them up and drive them home at the end of the two psilocybin sessions (around 5 p.m.).

For more detailed information about the study, visit www.bpru.org/cancer/insight. If you would like to discuss the possibility of volunteering, please call 410-550-5990. Confidentiality will be maintained for all applicants and participants.

PI: Roland R. Griffiths, Ph.D.
Protocol: NA_00001390

2. Do you know someone with cancer who is suffering from depression or anxiety?
A novel research study is happening now at Johns Hopkins that seeks to ease the psychological distress of people diagnosed with cancer.

To learn more, visit www.cancer-insight.org. Confidentiality will be maintained for all applicants and participants.

PI: Roland Griffiths, Ph.D.
NA_00001390

Commonly Used Medications

1. Have You Been Treated With Antibiotics?
Have you taken vancomycin, penicillin or amoxicillin for at least seven days within the past five years? OR, have you had an allergic reaction to these antibiotics within the past five years? Are you 18 to 70 years of age?

If so, you may be able to participate in a research study being done to learn why some people are allergic to certain antibiotics. The study involves two to four visits and two to four blood draws. Volunteers will be paid for their time.

Please call 410-550-2120.

Principal Investigator: N. Franklin Adkinson, M.D.
Study Number: NA_00014021

For further information, call 410-614-5174.

PI: Mark Riddle, M.D.
IRB #00017204

Diabetes

1. Do You Have Diabetes?
The Johns Hopkins Bayview Medical Center is conducting a study to find out if exercise reduces blood pressure and body fat, and improves fitness and cardiovascular health. If you have diabetes, are 40-65 years old and not smoking, you may be eligible. All visits are free, including parking, and qualified participants are eligible for additional compensation.

For more information, please call 410-550-5428/5429 or 410-550-5029.

RPN # 03-08-12-02
Principal investigator: Kerry J. Stewart, Ed.D.

2. Diabetic Subjects Needed For a Noninvasive MRI Scan Before and After a 3-Week Course of a Common Cholesterol-Lowering Medicine
We are seeking diabetic subjects to participate in a study designed to improve the way problems with blood vessels are evaluated and treated.

There are three visits in four weeks. An FDA-approved cholesterol tablet will be taken daily for three weeks with blood samples and MRI scans of the arm and leg before and after taking the medicine.

To qualify for the study, you must:

Have adult diabetes
Be between 40 and 90 years of age
Not currently smoke
Not currently take a cholesterol medicine

Other exclusions may apply. Compensation is provided. To see if you qualify, call 410-550-HART or 410-550-4328.

Protocol # NA_00002253
Principal Investigator: Harry A. Silber, M.D., Ph.D.

3. Do You Have Diabetic Neuropathy?
If you are 18-65 years old and a Type 1 or 2 diabetic suffering from moderate to severe burning, shocking, piercing or throbbing pain in your feet, you may qualify for a research study to evaluate the effectiveness of an investigational drug for painful diabetic peripheral neuropathy.

All office visits, medical evaluations and study drugs related to the study will be provided at no cost to participants.

Participants will be compensated for time and travel.

For more information, contact Nate Sweeney at 443-287-0589.

PI: Michaels Polydefkis
RPN: NA_00010088

4. VOLUNTEERS NEEDED FOR A RESEARCH STUDY ON TYPE 2 DIABETES AND SLEEP APNEA
To participate, you must be aged 18 years or older and have Type 2 diabetes. Participation will involve several clinical visits. Testing will include a sleep evaluation, an overnight sleep study, and monitoring of glucose and blood pressure. Participants will be compensated for your participation.

For more information or to participate, please contact Kelly Devine, RN, at 410-550-4891 or Melissa Minotti at 301-791-1847.

Principal Investigator: Naresh Punjabi, MD, Ph.D.
Protocol Number: NA_00019967

5. Do You Have Type 2 Diabetes?
Do everyday life problems make it harder to care for your diabetes? Would you like to learn more about ways to control blood sugar, blood pressure and cholesterol?

Project DECIDE is a research study at Johns Hopkins that tests different ways of giving education about taking care of diabetes, blood pressure and cholesterol. We want to know what works best for helping people care for their diabetes in daily life.

To be eligible to join the research study, you must be:

At least 25 years of age
Black/African American
Have a diagnosis of type 2 diabetes
Have a need for better control of your blood sugar, blood pressure and/or cholesterol

Participation will involve:

A screening to monitor your blood sugar, blood pressure and cholesterol to see if you qualify for the study.
If you are eligible:
- A visit to complete questionnaires
- Participation in one of four types of education about self-care for diabetes, blood pressure and cholesterol
- Follow-up visits to see how you are doing after completing the education

At each visit, you will receive monetary compensation for your time.

If you are interested in joining Project DECIDE, call 410-502-0662.

PI: Felicia Hill-Briggs, M.D.
NA_00018558

6. Improving Diabetes through Lifestyle and Surgery Study (IDeaLS)
The purpose of this study is to compare the effects of losing weight through:

Lifestyle changes (diet and exercise);
Surgery with gastric banding; or
Gastric bypass surgery, on improving diabetes.

This study is designed for patients who have mild to moderate obesity (BMI 30‐40 kg/m2) and have Type 2 Diabetes. Patients must have Employee Health Plan (EHP) insurance to take part in the study. Patients will have an equal chance of being randomized to one of the three treatment arms and will undergo detailed testing of their diabetes and other medical conditions. A total of 45 patients will be enrolled in the study protocol.

Find out more today by calling the IDeaLS study coordinator at 410-550-4472.

NA_00039135

7. Do you have Type 2 Diabetes? Do you have EHP (Employer Health Programs) insurance? Do you want to lose weight and improve your diabetes?

What is the purpose of the IDeaLS Study?

To see how weight loss affects diabetes.

Who is eligible?

Men and women 21-64 years of age with BMI 30-40 kg/m2 and EHP insurance.

What does the IDeaLS Study involve?

Screening visits in the clinic to determine if you are eligible.
If you are enrolled in the study, you would get one of the following weight loss interventions:
- Medical Weight Loss (diet, exercise and counseling)
- Roux-en-Y Gastric Bypass
or
- Adjustable Gastric Banding
Each participant is randomly assigned to one of these interventions.
You cannot choose which intervention you get.
In the study, you would get detailed testing for diabetes and metabolism.

Participants will be compnsated from $100-300. The costs of surgery or medical weight loss are covered by the study or by your EHP insurance.

For more information, please call 410-550-4472.

NA_00039135

Drug/Alcohol Use

1. Are You a Teenager Who Has Problems With ADHD and Uses Drugs or Alcohol?
Call to find out about a research study using study pills and counseling. You will receive assessments, study pills and therapy at no cost (no insurance needed).

You may be eligible if you are between the ages of 13 and 18. You will earn payment for participation!

For more information, please call 1-877-453-3399 or 410-233-1400, ex. 172.

PI: Geetha Subramaniam, M.D.
NA_00002443

2. Do you use cocaine?
If so, you may be able to participate in research studies to see how drugs affect the body and brain. The studies take place in East Baltimore and are sponsored by the National Institute on Drug Abuse (NIDA). You will receive money for your participation in a study.

For a confidential screening, call 800-535-8254 or 443-740-2295 or visit www.ResearchStudies.DrugAbuse.gov.

10.10.2012

3. Do you smoke cigarettes?
If so, you may be able to participate in research studies to see how smoking affects the body and brain. The studies take place in East Baltimore and are sponsored by the National Institute on Drug Abuse (NIDA). You will receive money for your participation in a study.

For a confidential screening, call 800-535-8254 or 443-740-2295 or visit www.ResearchStudies.DrugAbuse.gov.

10.10.2012

4. Research Volunteers Needed for Substance Abuse Study
Healthy males and females, ages 18 to 55, with a history of substance abuse involving opiates, such as heroin or morphine, are needed for an inpatient investigational drug study at the Clinical Studies Program at Johns Hopkins Bayview Medical Center. Participants will be compensated.

For more information, please call 410-550-0185.

PI: Donald R. Jasinski, M.D.
NA_00014298

5. Research on Cocaine Dependence
Are you an adult and concerned with your use of cocaine? Do you want to stop using cocaine?

A Johns Hopkins Bayview group is conducting a research study to see if an investigational medication helps treat cocaine dependence. Eligible participants will receive free study evaluations and medication. All information will be kept confidential. Compensation will be provided for time and travel.

For more information or to participate, please call 410-550-0185.

PI: Donald R. Jasinski, M.D.
NA_00011686

6. Marijuana Users Needed
Marijuana users, ages 18 and over, are needed to take part in a research study at Johns Hopkins.

This is NOT a treatment study. The study will involve staying at the Johns Hopkins Bayview Medical Center for approximately seven weeks. You will be compensated for your time and cooperation.

For more information, please call 410-550-2695.

PI: Ryan Vandrey, Ph.D.
NA_00026278

7. Seeking Treatment for Opiate Dependence?
If so, you may be able to participate in a research study that uses an FDA-approved medication to see if it works for easing the discomforts of detox from opiates. Participants receive buprenorphine-aided detox and counseling. There is no charge for participation. The studies take place in East Baltimore and are sponsored by the National Institute on Drug Abuse (NIDA).

For a confidential screening, call 1-866-START NOW or 443-740-2295 or visit www.ResearchStudies.DrugAbuse.gov.

10.10.2012

9. Have You Used Methamphetamine?
Methamphetamine users are needed for a medical research study. Volunteers should be between the ages of 18-45, in good general health and taking no regular medications. Testing will take place at the Johns Hopkins Bayview Medical Center and the Johns Hopkins Hospital in Baltimore, MD.

Volunteers will be paid for completion of all study procedures. Travel expenses will be covered. Please call 410-550-6266 or 410-550-2588.

Principal Investigator: Una D. McCann
IRB Number: NA_00031313

10. Research Volunteers
Research volunteers are needed who:

Have heroin or prescription drug dependence
Do not use any other drugs
Are in good health
Want detox

If you meet the above criteria and are willing to stay on a research unit for two months, you could earn up to $1,880.

For more information, call 410-550-0490. Ask for study #1003.

PI: Eric C. Strain, M.D.
NA_00031896

11. Cocaine Users Needed
Healthy men and women, ages 21 to 45, who regularly use cocaine are needed for a research study at Johns Hopkins Bayview Medical Center. The study requires a six-week stay at our residential research unit. This is NOT a treatment study.

Participants will be earn between $1,350 and $1,600.

Call 410-550-2799 for a phone screening to see if you qualify. Mention study #0908.

PI: Annie Umbricht, M.D.
NA_00026440

12. Investigational Treatment for Opioid Withdrawal
Are you 18-60 years old, currently addicted to heroin or prescription pain relievers and seeking treatment?

Researchers at Johns Hopkins Bayview Medical Center are conducting an residential research study to test an investigational medication for opioid withdrawal. Participation requires you to live on our residential research unit for up to 28 days.

If you qualify, you will receive study-related care at no cost and you will be compensated. You may earn up to $700.

Call 410-550-0490 for a phone screening.

PI: Eric C. Strain, M.D.
NA_00037871

13. Do You Have a Friend, Loved One or Co-Worker Trying to Stop Their Cocaine Use?
Johns Hopkins is testing an investigational vaccine to help reduce or stop cocaine use.

If you're regularly using cocaine and have a desire to reduce or quit their cocaine use, you may qualify. Compensation of up to $1,254 is available for this 18-week research study at the Johns Hopkins Bayview campus.

For more information or to find out if you qualify, call 410-550-1102 or visit www.bpru.org. Refer to study #1004.

PI: Maxine Stitzer, Ph.D.
NA_00020371

14. Research Study: Investigational Research on Heavy Drinking
Are you at least 18 years old and want to reduce your drinking?

Researchers at the Johns Hopkins Bayview campus conducting a research study testing a medication that may help people reduce their drinking.

Participation requires seven visits over about 16 weeks. Participation is confidential.

Compensation will be provided for your time and travel.

For more information or to find out if you qualify, call 410-550-1916.

PI: Eric C. Strain, M.D.
NA_00042017

15. Research Volunteers Needed
Healthy men and women, ages 21-50, are needed for a research study at the Johns Hopkins Bayview Medical Center. The study involves testing the effects of alcohol and other legal drugs.

Participation involves an initial screening session (about two hours) and seven experimental sessions (about six hours each).

You will be paid up to $800 for participation.

For more information, please call 410-550-3076.

PI: Roland Griffiths, Ph.D.
NA_00036826

16. Cocaine Users Needed
Healthy men and women, ages 18-65, who use cocaine on a regular basis, are needed to participate in a non-therapeutic research study at the Johns Hopkins Bayview Medical Center about decision-making.

This study requires two sessions lasting about four hours each. Sessions will involve questions about sexual behavior. HIV and Hepatitis C testing will be provided during the study.

Participants can earn $130 for completing both sessions.

For more information, please call 410-550-1916.

PI: Matthew W. Johnson, Ph.D.
NA_00027568

17. Seeking Hallucinogen Users Interested in Spirituality and Altered States of Consciousness
In recent years, scientists at some U.S. universities have been conducting studies using hallucinogens, resuming research in pharmacology, psychology, creativity and spirtuality that was suspended following the drug excesses of the 1960s.

Hallucinogens have been used for centuries in sacramental contexts in order to induce non-ordinary states of conciousness for spiritual purposes. Examples include the mescaline-containing peyote cactus used by the Native American Church, psilocybin-containing mushrooms uses as sacraments in Mesoamerica, and the DMT-containing ayahuasca used by various religious groups in South America.

A lesser-known hallucinogen, Salvia divinorum, is an herb in the sage family that has been used as a sacrament by the Mazatec people of Oaxaca, Mexico for hundreds of years. Recently, Salvia divinorum has also been used by hallucinogen users in the United States and other countries.

Researchers at The Johns Hopkins University are seeking volunteers who have used Salvia divinorum and other hallucinogens (for example, LSD or psilocybin mushrooms) to participate in a research study of states of conciousness brought about by the active principle constituent of Salvia divinorum (salvinorin A) given by inhalation, in a comfortable, supportive setting. Questionnaires and interviews will be used to assess the effects of the substance on conciousness, mood and behavior.

Volunteers enrolled in the study will receive careful preparation and up to 21 visits in which they will receive salvinorin A or placebo. Structured guidance will be provided during the sessions and afterwards to facilitate integration of the experiences. The research study complies with FDA regulations and is open to men and women.

Volunteers must be between the ages of 21 and 65, have no personal history of severe psychiatric illness, and must live within travel distance of Johns Hopkins Bayview Medical Center.

If you would like to discuss the possibility of volunteering, please call 410-550-5990 and ask for Mary, the study's research coordinator. Confidentiality will be maintained for all applicants and participants.

PI: Roland R. Griffiths, Ph.D.
NA_00009081

18. Free Research Treatment for Cocaine Abuse
If you have a friend, family member or co-worker, aged 18-60, that is seeking treatment for crack cocaine dependence, they may qualify for a treatment study. This study will test whether a study drug can help stop cocaine use, when combined with learning-based therapy.

The research study requires a screening, six orientation sessions, three weeks of active research treatment involving three visits per week, and seven follow-up visits that take place up to one month after research treatment.

Participants must not be dependent on opiods, such as heroin or methadone.

For more information or to enroll, please call 410-550-1102.

PI: Matthew W. Johnson, Ph.D.
NA_00046528

19. Effects of Prescription Oral Methamphetamine on Decision Making
Healthy men and women, ages 21-55, who have used stimulants to get high (such as cocaine, methamphetamine or amphetamine) in the last six months are needed to participate in a research study about the effects of prescription oral methamphetamine on decision making. This is not a treatment study.

The study requires one four- to five-hour screening visit and three overnight sessions lasting about 32 hours each. During each session, you will be required to remain overnight at a residential unit. Participants will earn up to $525 for completing the study.

For more information or to enroll, please call 410-550-9497.

PI: Matthew W. Johnson, Ph.D.
NA_00041057

20. Effects of Alcohol on Decision Making
Healthy men and women, ages 21-65, who have recently used alcohol are needed to participate in a research study about the effects of alcohol on decision making at Johns Hopkins Bayview Medical Center. This is not a treatment study.

The study requires one four- to five-hour screening visit and two sessions lasting about eight hours each. Participants will earn up to $200 for completing the study.

For more information or to enroll, please call 410-550-9497.

PI: Matthew W. Johnson, Ph.D.
NA_00067114

Headaches/Migraines

1. Do you suffer from migraines? Severe headaches?
A research study is being conducted on pre-menopausal women, ages 18-55, with episodic migraine, chronic migraine or healthy controls.

Participation includes:

Two study visits
Completion of questionnaires
Neurological exam
Obtaining fasting blood samples
DXA scan and abdominal MRI

If you're interested in participating, please contact Linda White, CRNP, study coordinator, at 410-550-4418.

PI: B. Lee Peterlin, D.O.
NA_00051683

2. Are you interested in participating in a research study comparing medications for migraine pain?
We are recruiting healthy women and men ages 18-65 with a history of migraines for at least one year.

The study includes:

Five study visits
Completion of headache questionnaires/calendar/diary
Physical examination
Treating migraines with two different nasal sprays/placebo

You will be paid $75 for participating in the study upon completion, and you will receive a paid parking voucher for each study visit.

If you're interested in participating, please contact Linda White, CRNP, study coordinator, at 410-550-9550.

PI: B. Lee Peterlin, D.O.
NA_00075486

Healthy Volunteers

1. Seeking Persons Committed to Spiritual Development to Participate in a Study of Mystical Experience, Meditation and Spiritual Practice
Researchers at The Johns Hopkins University School of Medicine are seeking volunteers who have an active interest in exploring and developing their spiritual lives to participate in a scientific study of the combined efforts of meditation, spiritual practice and the entheogen psilocybin, a psychoactive substance found in mushrooms used as a sacrament in some cultures.

The study will take place over six-eight months during which volunteers will be encouraged to initiate or maintain daily meditation and spiritual awareness practices. Volunteers will also receive careful preparation and 2-3 sessions in which they will receive psilocybin in a comfortable, supportive setting. Structured guidance will be provided during the session and afterwards to facilitate integration of the experiences.

For more detailed information about the study, visit www.bpru.org/spritual-practice. If you would like to discuss the possibility of volunteering, please call 410-550-2253 and ask for Maggie, the study coordinator. Confidentiality will be maintained for all applicants and participants.

PI: Roland R. Griffiths, Ph.D.
Protocol: NA_00020767

2. Healthy Individuals Needed
The goal of this study is to gain a better understanding of schizophrenia. We are seeking to compare individuals without schizophrenia to individuals who do have schizophrenia.

To be considered for the study, you must:

Be between the ages of 14-60 years old;
Be willing to have a blood sample drawn;
Be willing to provide a urine sample to test for drugs of abuse;
Have no history of stroke, brain tumor or serious brain injury;
Not consume alcohol or street drugs daily; and
Speak English.

Participation in the study involves:

Release of medical records;
Blood and urine sample; and
Clinical interview.

Participants will be paid $50 for their time. If you or someone you know might be interested in the study or have questions about the study, please call Nadine Yoritomo, RN, at (410) 502-5887.

PI: Russell Margolis, M.D.
RPN # NA_00009162

3. There May Be a Research Study For You
The National Institute on Drug Abuse (NIDA) conducts research studies to find out how various drugs, including nicotine, affect the body, the brain, and behavior.

Your part in a NIDA research study could help us better understand how the healthy brain works and how to prevent and treat drug abuse and addiction. The studies take place in East Baltimore area. All volunteers will receive money for their participation in a study.

If you are interested in being a healthy control in a NIDA research study, please call 1-800-535-8254 or 443-740-2295 or visit www.ResearchStudies.DrugAbuse.gov.

4. Research Study
This study includes one in-person visit, lasting approximately five hours. You may be eligible if you:

Are African American;
Are at least 18 years old;
Are very healthy;
Do not have chronic pain; and
Are not taking any medications.

The study involves measuring people's responses to sensory stimuli and drawing blood at several time points. There is no cost involved. Participants will receive compensation and reimbursement for parking.

For more information or to find out if you qualify, please call Kasey Bond at 0-6240.

PI: Jennifer A. Haythornthwaite, Ph.D.
NA_00036924

5. Research Study for Healthy Adults
Adults between the ages of 18 and 45 years are needed for a research study at The Johns Hopkins Hospital to look at an investigational inhaled drug for the treatment of flu. Participants will be admitted once or twice for three days and will return for additional visits in the outpatient clinic.

Basic study requirements include:

18-45 years of age
Non-smoker
Not pregnant or planning pregnancy

The study pays $1,500 to $2,000 at completion.

For more information or to see if you qualify, please call 410-955-1201.

PI: Jonathan Zenilman, M.D.
NA_00040913

6. Wanted: Healthy Adults

You may qualify for a research study to evaluate an investigational drug to treat C difficile diarrhea. Participants must:

be between 18 and 45 years old and be in good health
not be pregnant or planning a pregnancy

The study requires an inpatient stay of three days and taking an oral medication. Participants will be paid for their participation.

For more information or to find out if you qualify to enroll, call 443-691-7841 or 443-691-8618.

PI: Jonathan Zenilman, M.D.
NA_00068015

7. Health Seeking Behavior and Barriers to Healthcare in Black Men
The goal of this research study is to learn more about the experiences of black men when seeking medical care. We're looking for US-born African American men, 18 years of age or older, who live in the Baltimore metropolitan area.

Study participants will have a group discussion about why some black men go to the doctor and others do not. Participants will receive at light meal and a $20 gift card.

For more information or to see if you qualify, please call 443-287-8307

PI: Roland J. Thorpe Jr., Ph.D.
NA_00003571

8. Wanted: Healthy Adults
If you are a healthy non-smoker between 18 and 45 years old, you may qualify for a research study to evaluate an investigational drug for treatment of the flu.

The study requires an inpatient stay of three days, eight outpatient visits and taking an inhaled medication. Participants will be paid $2,000 for completion.

For more information, please call 443-691-7841.

PI: Jonathan Zenilman, M.D.
NA_00073763

9. Do you eat more when stressed?
If so, you may be able to participate in a research study to see if a new investigational drug can help people who overeat when stressed. The study takes place in East Baltimore and is sponsored by the National Institute on Drug Abuse (NIDA). You will receive money for your participation in a study.

For a confidential screening, call 1-800-535-8254 or 443-740-2295 or visit www.ResearchStudies.DrugAbuse.gov.

10. Are You A Healthy Pre-Menopausal Woman Without Pain?
A research study is being conducted on pre-menopausal women, ages 18-55, with episodic migraine, chronic migraine and healthy controls who do not suffer from migraines.

Participation includes:

Two study visits
Completion of questionnaires
Neurological exam
Obtaining fasting blood samples
DXA scan and abdominal MRI

If you're interested in participating, please contact Linda White, CRNP, study coordinator, at 410-550-4418.

PI: B. Lee Peterlin, D.O.
NA_00051683

Heart Disease/Cholesterol

1. Volunteers Needed
We are studying whether Alpha Lipoic acid, a potent antioxidant and over-the-counter product, reduces blood levels of markers of inflammation in the blood vessels when compared with placebo. Placebo is a substance that looks like the real product, but contains no active product. There will be up to six visits in 12 weeks. Blood tests will be done to check glucose and cholesterol levels to help determine your study eligibility.

Inclusions:

Male or female, aged 40 to 80 years
If female, you must be post-menopausal or sterilized and not be on hormone therapy
In addition, you must have at least three of the following conditions:
- Controlled diabetes, but not taking medication
- Moderately overweight
- Stable high blood pressure
- High cholesterol, but are not taking a statin medication

Exclusions:

Current or recent smoking
Previous heart attack or stroke
Some medications or other medical conditions may exclude you from participating

Compensation is available. For more information or to participate in the study, please call 410-550-HART (4278).

PI: Pamela Ouyang, MBBS
NA_00016646

Memory

1. Do you have more trouble than usual remembering things?
People 55 and older with memory problems are needed for a research study at Johns Hopkins Bayview.

The study will find out if mentally stimulating activities can improve memory and other types of thinking. Participation involves one screening visit, four visits lasting four hours each and 17 visits lasting one hour each.

Participants will be paid $620 at completion.

For more information, please call 410-550-2688.

PI: Miriam Z. Mintzer, Ph.D.
NA_00039100

Pregnancy

1. Exercise & Pregnancy Research
We are looking for pregnant women to participate in a research study looking at the effects of exercise on the fetus. Women who exercise regularly and those that do not exercise are able to participate.

The study involves one to three exercise sessions. Testing will be performed between 28 and 32 weeks of pregnancy and will involve fetal heart rate monitoring and ultrasound before and after exercise.

For more information, please contact Linda Szymanski, M.D., Ph.D., at 410-961-2095.

PI: Andrew Satin, M.D.
NA_00027801

Sleep

1. VOLUNTEERS NEEDED FOR A RESEARCH STUDY ON TYPE 2 DIABETES AND SLEEP APNEA
To participate, you must be aged 18 years or older and have Type 2 diabetes. Participation will involve several clinical visits. Testing will include a sleep evaluation, an overnight sleep study, and monitoring of glucose and blood pressure. Participants will be compensated for your participation.

For more information or to participate, please contact Kelly Devine, RN, at 410-550-4891 or Melissa Minotti at 301-791-1847.

Principal Investigator: Naresh Punjabi, MD, Ph.D.
Protocol Number: NA_00019967

2. Have you been told you snore? Do you need to lose weight?
Johns Hopkins Medicine is conducting a research study in persons who may snore and are not currently being treated for snoring. Eligible participants must be over 60 years of age, overweight, not smoking and not regularly exercising.

All visits are free, including parking, at the Johns Hopkins Bayview Medical Center.

For more information, please call 410-550-5428, 410-550-5429 or 410-550-6997.

Principal Investigator: Devon A. Dobrosielski, PhD
IRB# NA_00040314

Smoking

1. Do you smoke cigarettes?
If so, you may be able to participate in research studies to see how smoking affects the body and brain. The studies take place in East Baltimore and are sponsored by the National Institute on Drug Abuse (NIDA). You will receive money for your participation in a study.

For a confidential screening, call 800-535-8254 or 443-740-2295 or visit www.ResearchStudies.DrugAbuse.gov.

2. Cigarette Smokers Interested in a Spiritual Approach to Quitting Smoking
The Johns Hopkins University School of Medicine is seeking smokers who want to quit smoking to participate in a scientific study of spiritual/mystical experience brought about by psilocybin, a psychoactive etheogen (roughly meaning God-evoking substance) found in mushrooms used as a sacrament in some cultures, given in a comfortable, supportive setting.

Some studies have suggested that entheogens, when administered under interpersonally supportive and well-prepared conditions, are effective in helping people overcome addictions. Cognitive behavior therapy and ongoing interpersonal support will be integrated with psilocybin sessions in order to help participants quit smoking.

Questionaires, interviews and biological measures of smoking will be used to assess the treatment's effects on consciousness, mood and smoking. Volunteers enrolled in the study will receive careful preparation and three sessions in which they will receive psilocybin. Structured guidance will be provided during the sessions and afterwards to facilitate integration of the experiences. The study complies with FDA regulations.

Volunteers must be between 21 and 65 years of age, have no personal history of severe psychiatric illness or recent history of alcoholism or drug abuse, have someone willing to pick them up and drive them home at the end of the two psilocybin sessions (around 5 p.m.), and must live within travel distance of the Johns Hopkins Bayview campus.

If you would like to discuss the possibility of volunteering, please call 410-550-5990 and ask for Mary. Confidentiality will be maintained for all applicants and participants.

PI: Matthew W. Johnson, Ph.D.
Protocol: NA_00016166

3. Do You or Someone You Know Want to Quit Smoking?
The Smoking Clinic at the Johns Hopkins Bayview Medical Center currently is recruiting adult cigarette smokers who are trying to quit for a research study. We are testing medications to help smokers quit.

The 10-week study requires 12 visits to Johns Hopkins Bayview Medical Center. Scheduling is flexible. Treatment is free. Participants will be compensated for their time.

For more information or to find out if you're eligible, please call 410-550-2799.

PI: Annie Umbricht, M.D.
NA_00074143

4. Are you ready to quit smoking?

If so, you may be able to participate in research studies that provide treatment to help people stop smoking cigarettes. Participants receive at no cost:

Medication or nicotine substitute
Counseling

You will also receive money for your time and travel.

The studies take place in East Baltimore and are sponsored by the National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), & U.S. Department of Health and Human Services.

For a confidential screening, call 1-800-535-8254 or 443-740-2295, or visit www.ResearchStudies.DrugAbuse.gov.

Vaccines

1. Influenza Vaccine Study
The Division of Geriatric Medicine and Gerontology is looking for individuals, either between ages 18 and 74, or ages 75 and older, to participate in an influenza vaccination study that will evaluate immune function in older adults.

To determine whether you are eligible for the study, we will ask some questions about your health over the phone. If you are eligible and agree to participate, you will receive a brief history and physical exam by a doctor, as well as the influenza vaccine (flu shot). You also be asked to donate blood samples before and after the "flu shot." We will follow up with you by phone to check on how you're doing throughout the flu season (usually lasts until the end of April).

For more information, please contact the study coordinator at 410-550-2113.

PI: Sean X. Leng, M.D., Ph.D.
NA_00004478

Vascular Disease

1. NIH-Sponsored Peripheral Arterial Disease (PAD) Clinical Trial Recruiting Patients at Johns Hopkins Bayview
Peripheral arterial disease (PAD) is a major source of morbidity and mortality, particularly in older individuals. Claudication (leg pain with walking, typically relieved with rest) may be a symptom of PAD.

Claudication: Exercise Versus Endoluminal Revascularization (CLEVER) is a prospective, randomized, multicenter clinical trial designed to determine optimal treatment for claudication due to aortoiliac disease. It compares the benefits of supervised exercise, endovascular revascularization and optimal medical care.

Who may be eligible: Age 40 and older with intermittent claudication due to aortoiliac peripheral arterial disease

If you are interested in learning more about this research study or if you have a patient who may be eligible, please call the Johns Hopkins Center for Vascular Medicine at 410-955-5897.

PI: Elizabeth Ratchford, M.D.
NA_00015857

2. Venous Leg Ulcers
Do you have venous stasis disease? Do you have a leg ulcer? Johns Hopkins Wound Center is conducting a research study on venous leg ulcers using an advanced biologic skin repair therapy.

Patients with six-week to two-year-old venous leg ulcers are needed to participate in the study. Participants would come to the wound clinic at Johns Hopkins Bayview on a weekly basis for spray application of study skin cells and free comprehensive wound care, including dressings, pressure wraps and shoes.

Study participants will be compensated $35 per visit. Approximately 15 visits are required.

For more information or to find out in you're eligible to participate, please contact Yolanda Johnson at 410-550-4724.

PI: Gerald Lazarus, M.D.
NA_00027356

3. Are you between 8-20 weeks pregnant? Would you like to participate in a research study?
The Johns Hopkins Vein Center is conducting a non-invasive research study to evaluate the effect of compression stocking use in preventing the development of venous insufficiency. Venous insufficiency is a condition in which the veins have problems sending blood from the legs back to the heart. It can cause:

Varicose veins
Skin changes
Leg swelling
Pain
Non-healing ulcers
Thrombophlebitis

To be eligible for this study you must be:

Female between 18-45 years of age
Between 8-20 weeks pregnant
Seeking care for pregnancy at one of these Johns Hopkins locations: Johns Hopkins Bayview, Johns Hopkins Hospital or Johns Hopkins at White Marsh
Able to undergo two ultrasound exams on the legs
Able to attend three appointments & participate in phone interviews

PI: Jennifer Heller, M.D.
NA_00047720

Women's Health

1. Adolescents and Birth Control Study
If you are a young woman between the ages of 13 and 21 years, you may be eligible for a research study. Recruitment for this research study is to find out what young women think about sex, relationships, pregnancy and birth control. We are especially interested in comparing young women who have HIV and young women who do not have HIV.

If you are eligible to participate, you will be asked to complete a survey on a computer. All your answers will be kept confidential (nobody outside the study will see them).

You will receive a $20 gift card to thank you for participating and compensation for travel.

For more information, call 410-550-3060.

PI: Jenny Robinson, M.D., MPH
Protocol: NA_00050109

2. Want to Participate in a Research Study on a Contraceptive Vaginal Ring?
If you are a healthy woman between the ages of 18 and 39, and have regular menstrual cycles, you may be eligible for a research study of a method of birth control.

This study will evaluate the effects of receiving two birth control hormones in a vaginal ring.

Multiple, frequent study visits over an eight month period
Visits will occur at Johns Hopkins Bayview
Participants should be using a non-hormonal method of contraception, or not be at risk for pregnancy
Compensation for participation and travel

For more information or to enroll, please call 410-550-3060.

PI: Anne E. Burke, M.D., MPH
NA_00068632

3. Are you starting hormonal birth control?
If you are a healthy woman between the ages of 16 and 35, you may be eligible to participate in the Hormonal Contraception Longitudinal Study.

The purpose of this research study is to follow the immune responses and normal bacterial communities of the reproductive tracts of women starting, already on, or not on hormonal contraception for a period of two years. We would like to better understand how the length of HC use affects these responses and communities.

Enrollments will be taking place at the Johns Hopkins Bayview, White Marsh, and Green Spring Station gynecology clinics.

The research study requires eight total clinic visits. Subjects will be financially compensated for both clinic visits and specimen collections. Transportation and parking costs will also be provided.

For more information, call our study coordinator at 410-550-8698 or visit www.hopkinsbayview.org/HCLStudy.

PI: Khalil Ghanem, MD, PhD
NA_00043112

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